Diisopropylethylamine → HCID 86688912, compound

Participants

Reaction Steps

Ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol), 3,5-dimethylpiperidine (0.20 ml, 1.48 mmol), and DIPEA (0.26 ml, 1.48 mmol) were dissolved in acetonitrile (12 ml) and stirred at room temperature for 16 hours. Acetonitrile was evaporated and the crude was purified by flash chromatography (Petroleum ether/EtOAc=95/5) to obtain ethyl 2-(3,5-dimethylpiperidin-1-yl)-2-phenylacetate (203 mg, 59.7% yield) as colourless oil.

Provenance & Evidence