Phenacyl bromide → HCID 86688914, compound

Participants

Reaction Steps

(R)-quinuclidin-3-yl 2-(3,5-dimethylpiperidin-1-yl)-2-phenylacetate (120 mg, 0.34 mmol) and 2-bromo-1-phenylethanone (73.7 mg, 0.37 mmol) were dissolved in acetonitrile (5 ml) and stirred at room temperature for 16 hours. Acetonitrile was evaporated, the residue was taken up with little EtOAc (2 ml) and then Et2O was added. The white solid that precipitated out was recovered by suction filtration and washed on the filter paper with Et2O. The solid was dried to obtain (3R)-3-(2-(3,5-dimethylpiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (115.8 mg, 61.9% yield).

Provenance & Evidence