2-Chloroacetophenone → HCID 86688917, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (31.0 mg, 0.20 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(4,4-difluoropiperidin-1-yl)-2-phenylacetate (24b) (73 mg, 0.20 mmol) in ethyl acetate (3 ml). The reaction was stirred at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was triturated with Et2O (4 ml). A white precipitate was formed and it was collected by suction filtration and dried under vacuum at 40° C. overnight, to obtain (3R)-3-(2-(4,4-difluoropiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (81 mg, 78% yield).

Provenance & Evidence