2-Chloroacetophenone → HCID 86688924, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-((R)-2-methylpyrrolidin-1-yl)-2-phenylacetate (24c) (44 mg, 0.13 mmol) was dissolved in a mixture ethyl acetate (0.9 ml) and acetonitrile (0.4 ml). 2-Chloro-1-phenylethanone (22.8 mg, 0.15 mmol) was added and the mixture was stirred at room temperature for 48 hours. The solution was evaporated and the residue was purified first by flash chromatography (DCM/MeOH=90/10 to 85/15) and then by trituration with Et2O/DCM (about 5/1) to obtain the title compound (23 mg, 35.5% yield) as a pale yellow solid.

Provenance & Evidence