Diethyl Ether → (3R)-3-(2-(4-fluorophenyl)-2-(piperidin-1-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride

Participants

Reaction Steps

2-Chloro-1-phenylethanone (29.5 mg, 0.19 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(4-fluorophenyl)-2-(piperidin-1-yl)acetate (60 mg, 0.17 mmol) in EtOAc (3 ml). 2-Chloro-1-phenylethanone (8.85 mg, 0.06 mmol) were added and stirring was kept for 4 additional hours. Et2O was added and the precipitate was collected by suction filtration to obtain (3R)-3-(2-(4-fluorophenyl)-2-(piperidin-1-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (49.9 mg, 57.5% yield) as a gummy yellow solid.

Provenance & Evidence