2-Chloroacetophenone → HCID 86688948, compound

Participants

Reaction Steps

(R)-quinuclidin-3-yl 2-(2,4-difluorophenyl)-2-(piperidin-1-yl)acetate (275 mg, 0.75 mmol) and 2-chloro-1-phenylethanone (128 mg, 0.83 mmol) were dissolved in acetonitrile (8 ml) and stirred at room temperature overnight. The solvent was evaporated and the residue was triturated with Et2O and sonicated. The resulting precipitate was recovered by suction filtration and washed on the filter-paper with EtOAc and Et2O to obtain the title compound (261 mg, 66.6% yield) as a white solid.

Provenance & Evidence