Acetonitrile → HCID 86688950, compound

Participants

Reaction Steps

A mixture of 2-oxoacetic acid hydrate (216 mg, 2.34 mmol), piperidine (0.23 ml, 2.34 mmol) and thiophen-2-ylboronic acid (300 mg, 2.34 mmol) in acetonitrile (11.7 ml) was heated to reflux for 2.5 hours. The reaction was cooled at room temperature and the suspension was filtered on a buckner funnel washing with acetonitrile (10 ml). The solid was recovered from the filter giving the title compound (528 mg, quantitative yield) as a white solid.

Provenance & Evidence