2-Chloroacetophenone → HCID 86688951, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (63.0 mg, 0.41 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(piperidin-1-yl)-2-(thiophen-2-yl)acetate (124 mg, 0.37 mmol) in ethyl acetate (2.5 ml) and acetonitrile (1.2 ml). The pale yellow solution was stirred at room temperature for 24 hours. The solvent was evaporated and the residue was triturated with Et2O (8 ml). The suspension was filtered on a buckner funnel washing with Et2O (5 ml) and the solid was recovered from the filter to collect the title compound (88 mg, 48.5% yield) as a off-white solid.

Provenance & Evidence