Piperidine → HCID 43803863, compound

Participants

Reaction Steps

Thiophen-3-ylboronic acid (300 mg, 2.34 mmol) was added to a solution of 2-oxoacetic acid hydrate (216 mg, 2.34 mmol) and piperidine (0.23 ml, 2.34 mmol) in acetonitrile (11.7 ml). The mixture was heated to reflux for 5 hours. The reaction was cooled to room temperature and the suspension was filtered on a buckner funnel washing with acetonitrile (8 ml). The title compound (528 mg, quantitative yield) was collected from the filter as an off-white solid.

Provenance & Evidence