2-Chloroacetophenone → HCID 86688954, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (107 mg, 0.69 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(piperidin-1-yl)-2-(thiophen-3-yl)acetate (210 mg, 0.63 mmol) in EtOAc (4.2 ml) and acetonitrile (2.1 ml) and. The mixture was stirred at room temperature for 48 hours. The solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=9/1) to collect the title compound (117 mg, 38.1% yield) as an off-white spongy solid.

Provenance & Evidence