HCID 59497113, compound → HCID 59497082, compound

HRID 404699Notes

Reaction equation

HRID 404699 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH:16]2[CH2:18][CH2:17]2)[C:11](=[O:19])[C:10]=1[C:20]([F:23])([F:22])[F:21])C1C=CC=CC=1>[Pd].C(O)C>[CH:16]1([CH2:15][N:12]2[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([C:20]([F:21])([F:22])[F:23])[C:11]2=[O:19])[CH2:18][CH2:17]1

Participants

4

Reactant 1

HCID 59497113HCID 59497113, compound

Product 1

HCID 59497082HCID 59497082, compoundYield 100.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of intermediate D7 (2.0 g, 6.19 mmol), a catalytic amount of 10% palladium on activated carbon and ethanol (60 ml) was stirred under hydrogen atmosphere for 2 hours. The mixture was filtered through diatomaceous earth and the solvent was evaporated in vacuo to yield crude intermediate D8 (1.45 g, 100%) that was used without further purification.

Workup

  1. filtrationThe mixture was filtered through diatomaceous earth
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-d14afe802c1a46f2a9390db5f3d575af
Source dataset
uspto-grants-2014_06
Patent number
US08748621B2

Reaction notes

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