HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-aminoazetidine-1-carboxylate → 6-(Azetidin-3-ylamino)-2H-isoquinolin-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-aminoazetidine-1-carboxylate | HCID 1516507 | — |
| Reactant | 6-Bromo-2-[(4-methoxyphenyl)methyl]-1(2H)-isoquinolinone | HCID 57551771 | — |
| Reactant | Isoquinolin-6-yl-piperidin-4-yl-amine Hydrochloride | HCID 68594013 | — |
| Product | 6-(Azetidin-3-ylamino)-2H-isoquinolin-1-one hydrochloride | HCID 68592668 | — |
Reaction Steps
6-(Azetidin-3-ylamino)-2H-isoquinolin-1-one hydrochloride was prepared by Buchwald Reaction starting from 6-Bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (13) and 3-Amino-azetidine-1-carboxylic acid tert-butyl ester. BOC deprotection was performed as described for Isoquinolin-6-yl-piperidin-4-yl-amine (48).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-59345b38e02f4c92a1e300afb27f7c6d |
| Source note | uspto-grants-2014_06 |