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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404738Generated: October 26, 2026

6-Bromo-7-chloroisoquinoline → (Rac)-7-chloro-6-(piperidin-3-ylsulfanyl)-isoquinoline hydrochloride

https://huagongshe.com/reaction/404738

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromo-7-chloroisoquinolineHCID 53418615—
Reactant3-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester (Rac)-7-Chloro-6-(piperidin-3-ylsulfanyl)-isoquinolineHCID 131731600—
Product(Rac)-7-chloro-6-(piperidin-3-ylsulfanyl)-isoquinoline hydrochlorideHCID 68592505—

Reaction Steps

Starting from 6-Fluoro-7-chloroisoquinoline (263) and 3-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester (Rac)-7-Chloro-6-(piperidin-3-ylsulfanyl)-isoquinoline could be obtained as the hydrochloride as described for compound (268). Rt=0.80 min (Method B). Detected mass: 279.1/281.1 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748614B2
Source datasetuspto-grants-2014_06
ORD IDord-b6d25bb6b0f04d459105aaeedccc8523
Source noteuspto-grants-2014_06