HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-7-chloroisoquinoline → (Rac)-6-(azepan-4-ylsulfanyl)-7-chloro-isoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-7-chloroisoquinoline | HCID 53418615 | — |
| Reactant | 4-Hydroxy-azepane-1-carboxylic acid tert-butyl ester (Rac)-6-(Azepan-4-ylsulfanyl)-7-chloro-isoquinoline | HCID 131731601 | — |
| Product | (Rac)-6-(azepan-4-ylsulfanyl)-7-chloro-isoquinoline hydrochloride | HCID 68592748 | — |
Reaction Steps
Starting from 6-Fluoro-7-chloroisoquinoline (263) and 4-Hydroxy-azepane-1-carboxylic acid tert-butyl ester (Rac)-6-(Azepan-4-ylsulfanyl)-7-chloro-isoquinoline could be obtained as the hydrochloride as described for compound (268). Rt=0.83 min (Method B). Detected mass: 293.1/295.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-dec60f9e7a364253bf670b0408b25352 |
| Source note | uspto-grants-2014_06 |