tert-Butyl 4-bromopiperidine-1-carboxylate → tert-Butyl 4-(acetylthio)piperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

2.2 g (19.3 mmol) Potassium thioacetate and 2.65 g (10 mmol) 4-Bromo-piperidine-1-carboxylic acid tert-butyl ester were dissolved in 50 ml of DMF and stirred at 100° C. for 4 h. The mixture was taken up in ethyl acetate and washed with brine. The organic phases were dried over Sodium sulfate and evaporated. Purification over silica gel (10% to 20% ethyl acetate in heptane) gave 2.15 g of the expected compound.

Provenance & Evidence