HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → tert-Butyl 4-sulfanylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Hydroxy-1,2,3-propanetricarboxylic acid hydrate (1:1) | HCID 22230 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | tert-Butyl 4-(acetylthio)piperidine-1-carboxylate | HCID 22494773 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 4-sulfanylpiperidine-1-carboxylate | HCID 21906090 | 98.8% |
Reaction Steps
2.15 g 4-Acetylsulfanyl-piperidine-1-carboxylic acid tert-butyl ester (272) were dissolved in 84 ml MeOH and treated with 2.1 g (55.5 mmol) sodium borohydride at 0° C. after stirring for 2 h at RT all volatiles were removed in vacuo and to the residue was added slowly water and 2.3 g (11 mmol) citric acid monohydrate. Extraction with dichloromethane, drying with Sodium sulfate and evaporation gave 1.78 g of crude 4-Mercapto-piperidine-1-carboxylic acid tert-butyl ester
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-0d6a642b236646698391dbbdf1146283 |
| Source note | uspto-grants-2014_06 |