HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Chloro-6-(piperidin-4-ylsulfanyl)-isoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(7-Chloro-isoquinolin-6-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 59290823 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Chloro-6-(piperidin-4-ylsulfanyl)-isoquinoline hydrochloride | HCID 68591636 | 224.6% |
Reaction Steps
1.98 g of 4-(7-Chloro-isoquinolin-6-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester (274) were dissolved in 7 ml dichloromethane and 5 ml 6N HCl in isopropanol. After 18 h at RT the volatiles were evaporated, water was added and lyophilized. 1.85 g of the expected compound were obtained. Rt=0.70 min (Method B). Detected mass: 279.1/281.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-0f36255771924c9eb17b6261aac113d5 |
| Source note | uspto-grants-2014_06 |