HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Chloro-6-(piperidin-4-ylmethylsulfanyl)-isoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Bromo-7-chloroisoquinoline | HCID 53418615 | — |
| Reactant | 4-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester 7-Chloro-6-(piperidin-4-ylmethylsulfanyl)-isoquinoline | HCID 68592395 | — |
| Product | 7-Chloro-6-(piperidin-4-ylmethylsulfanyl)-isoquinoline hydrochloride | HCID 68594470 | — |
Reaction Steps
Starting from 6-Fluoro-7-chloroisoquinoline (263) and 4-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester 7-Chloro-6-(piperidin-4-ylmethylsulfanyl)-isoquinoline could be obtained according to the procedures described for 272, 267, 268 as the hydrochloride. Rt=0.78 min (Method B). Detected mass: 293.1/295.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-ed753e78e49d4709828b9015dc0a3ce3 |
| Source note | uspto-grants-2014_06 |