HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one → 4-[7-Chloro-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one | HCID 59226259 | — |
| Reactant | 7-Chloro-6-(piperidin-4-ylsulfanyl)-2H-isoquinolin-1-one | HCID 59290782 | — |
| Reactant | 4-(7-Chloro-isoquinolin-6-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 59290823 | — |
| Product | 4-[7-Chloro-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 59290679 | — |
Reaction Steps
Starting from 7-Chloro-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (264) 4-[7-Chloro-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-ylsulfanyl]-piperidine-1-carboxylic acid tert-butyl ester could be obtained as described for compound (274). 7-Chloro-6-(piperidin-4-ylsulfanyl)-2H-isoquinolin-1-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748614B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-66a21d1c1c394449ba4a3b1f597c4201 |
| Source note | uspto-grants-2014_06 |