反应详情

To a solution of ethyl 3-bromo-2-oxo-4-phenylbutanoate (13.8 g, 48.4 mmol) in MeOH (161 mL) was slowly added 2,5-difluorobenzothioamide (8.38 g, 48.4 mmol) at room temperature. The reaction mixture was then refluxed for overnight. After cooled down, white precipitate was filtered, washed by cold ethanol and dried. A mixture of methyl 5-benzyl-2-(2,5-difluorophenyl)thiazole-4-carboxylate and ethyl 5-benzyl-2-(2,5-difluorophenyl)thiazole-4-carboxylate (10.5 g, 61%) was obtained as white solid. LC/MS (uplc): MW 346.1, 1.21 min for methyl ester; 360.1, 1.27 min for ethyl ester.

1. customat room temperature
2. temperatureThe reaction mixture was then refluxed for overnight
3. temperatureAfter cooled down
4. filtrationwhite precipitate was filtered
5. washwashed by cold ethanol
6. customdried
7. additionA mixture of methyl 5-benzyl-2-(2,5-difluorophenyl)thiazole-4-carboxylate