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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404881Generated: October 27, 2026

Water → n-Hydroxy-4-(4-isopropoxyphenoxy)benzenecarboximidoyl chloride

https://huagongshe.com/reaction/404881

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantChlorosuccinimideHCID 31398—
Reactant4-(4-Isopropoxyphenoxy)benzaldehyde oximeHCID 131731604—
SolventDimethylformamideHCID 6228—
Productn-Hydroxy-4-(4-isopropoxyphenoxy)benzenecarboximidoyl chlorideHCID 131731605104.2%

Reaction Steps

To a solution of Example 17C (1.48 g, 5.56 mmol) in N,N-dimethyl formamide (15 mL) was added N-chlorosuccinimide (0.70 g, 5.24 mmol) at room temperature. The mixture was stirred at room temperature overnight. The mixture was poured into water. The aqueous layer was extracted with ether washed with water, then brine, and dried over MgSO4 and concentrated to give the title compound as an oil (1.67 g, 100%),

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748627B2
Source datasetuspto-grants-2014_06
ORD IDord-4445b2fac22d455bbc5e5c64ace595d9
Source noteuspto-grants-2014_06