Isopropanol → 2-(2-Chloro-4-isopropoxyphenoxy)-1,3-thiazole

참여 물질

역할	이름	HCID	투입량
반응물	Isopropanol	HCID 3776	—
반응물	Triphenylphosphine	HCID 11776	—
반응물	ethyl N-ethoxycarbonyliminocarbamate	HCID 220568	—
반응물	3-Chloro-4-(1,3-thiazol-2-yloxy)phenol	HCID 69169394	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	2-(2-Chloro-4-isopropoxyphenoxy)-1,3-thiazole	HCID 69436904	89%

반응 단계

To a mixture of Example 9B (2.3 g, 0.01 mol), isopropanol (1.2 mL, 0.015 mol) and triphenylphosphine (3.93 g, 0.015 mol) in dry tetrahydrofuran was added diethyl azodicarboxylate (2.61 g, 0.015 mol) drop wise and the reaction was stirred at room temperature overnight. The solvent was removed and the residue was purified on silica gel (ethyl acetate/hexane, 5˜35%) to give 2.4 g of product as a light yellow oil (89% yield), 1H NMR (300 MHz, CDCl3) δ ppm 1.35 (d, J=5.88 Hz, 6H) 4.42-4.57 (m, 1H) 6.76-6.86 (m, 2H) 6.99 (d, J=2.94 Hz, 1H) 7.19 (d, J=3.68 Hz, 1H) 7.23 (s, 1H), MS (ESI) m/z 269.9 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08748627B2
출처 데이터셋	uspto-grants-2014_06
ORD ID	ord-97f736f9d04f494ca8469431e78d3212
출처 메모	uspto-grants-2014_06