Dichloromethane → HCID 23648838, compound

Participants

Reaction Steps

A solution of Example 40C (372 mg, 0.78 mmol) in 9:1 dichloromethane:ethanol (25 mL) was charged with hydrazine hydrate (379 uL, 7.8 mmol) and refluxed for 4 hours. The solvent was removed under vacuum and the reaction mixture was stirred in dichloromethane for 3 hours. The solid was removed by filtration and the residue was concentrated under vacuum to yield 265 mg of the title compound. 1H NMR (300 MHz, CDCl3) δ ppm 7.91 (s, 1H) 7.15-7.25 (m, 2H) 6.88-7.00 (m, 2H) 4.46-4.61 (m, 1H) 4.28-4.41 (m, J=6.86 Hz, 1H) 1.58 (d, J=6.99 Hz, 3H) 1.36 (d, J=5.88 Hz, 6H). MS (DCI): m/z 347 (M+H)+.

Provenance & Evidence