反应详情

温度

80 °C

Under a nitrogen atmosphere, a solution prepared by dissolving 571 mg (2 mmol) of N-phenoxycarbonyl-L-phenylalanine and 184 mg (2 mmol) of phenol in 20 mL of 2-butanone was charged into a two-necked round bottom flask having a volume of 100 mL and mounted with a Dimroth condenser, and was then stirred at 80° C. for 8 hours. The fact that N-carboxy-phenylalanine anhydride was obtained in a yield of 99% or more was confirmed by subjecting the reaction mixture to NMR determination.

1. customUnder a nitrogen atmosphere, a solution prepared
2. additionwas charged into a two-necked round bottom flask