反应详情

To a stirred solution of sodium azide (3.5 g, 50 mmol) in water (25 mL) was added a solution of 1,3-propane sultone (6.1 g, 50 mmol) in acetone (25 mL). The reaction mixture was stirred at room temperature for 24 h then concentrated to dryness. The resulting solid was suspended in diethyl ether (100 mL) and stirred at reflux for 1 h. The suspension was cooled to room temperature and the solid was collected by filtration, washed with acetone and diethyl ether, and dried under vacuum, affording of 3-azido-1-propanesulfonic acid (7.6 g, 80%).

1. concentrationthen concentrated to dryness
2. stirringstirred
3. temperatureat reflux for 1 h
4. temperatureThe suspension was cooled to room temperature
5. filtrationthe solid was collected by filtration
6. washwashed with acetone and diethyl ether
7. customdried under vacuum