Sodium Chloride → Acetophenone

Participants

Reaction Steps

Fe(NO3)3.9H2O (16.1607 g, 40.0 mmol), TEMPO (6.2510 g, 40.0 mmol), NaCl (2.3377 g, 40.0 mmol) and DCE (400 mL) were added to a 2 L-three-necked flask, and were stirred for 10 mins at room temperature under oxygen atmosphere. 1-Phenyl ethanol (488.64 g, 4.0 mol) was then added dropwise to the reaction solution. The reaction was exothermic, and the reaction temperature was kept below 50° C. The reaction was monitored by TLC till it was complete. The reaction solvent DCE was recovered after distillation under atmospheric pressure (350 mL, recovery of 88%) and acetophenone was obtained after further distillation under reduced pressure (b.p. 98˜100° C./20 mmHg, 436.6414 g, 91%).

Provenance & Evidence