HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Acetamido-4-phenyl-1,3-thiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-acetamido-4-phenylthiazole-5-carboxylate | HCID 3941062 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Acetamido-4-phenyl-1,3-thiazole-5-carboxylic acid | HCID 82226535 | — |
Reaction Steps
To 2.2 g (7.62 mmol) 2-acetylamino-4-phenyl-thiazole-5-carboxylic acid ethyl ester in 10 mL water is added 5 mL 4N NaOH and the mixture is allowed to stand at rt for 12 h. 1 g LiOH is added and the mixture is allowed to stand at rt for 2 h. The mixture is neutralized with aq. 2 N HCl solution and the precipitate is collected and washed with water and ACN to yield the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530461B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-496a958ae2bf4b89a73f788ab13f82d9 |
| Source note | uspto-grants-2013_09 |