Hydroxyamine hydrochloride → HCID 58032534, compound

Participants

Reaction Steps

3-[3-Fluoro-4-(hydroxy-hydroxyimino-methyl)-phenyl]-2-[(4′-methyl-biphenyl-3-carbonyl)-amino]-propionic acid tert-butyl ester. A mixture of 3-(4-cyano-3-fluoro-phenyl)-2-[(4′-methyl-biphenyl-3-carbonyl)-amino]-propionic acid tert-butyl ester (10 g, 0.02 mol), hydroxylamine hydrochloride salt (7 g, 0.1 mol), and NaHCO3 (10 g, 0.12 mol) in ethanol (150 mL) was refluxed overnight. TLC showed the reaction was completed. The mixture were filtered and concentrated to give the title compound (10 g, 93% yield).

Provenance & Evidence