Acetic Anhydride → 4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

HRID 40503Notes

Reaction equation

HRID 40503 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH2:11])[O:9][CH:10]=1)=[O:5])[CH3:2].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[O:9][CH:10]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 319549Ethyl 2-amino-1,3-oxazole-4-carboxylate

Product 1

HCID 2153734-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

Procedure

1.0 g (6.40 mmol) 2-Amino-oxazole-4-carboxylic acid ethyl ester and 9.1 mL (96.3 mmol) acetic acid anhydride are stirred for 2 d at rt. The mixture is concentrated in vacuo to yield the desired product which is used without further purification.

Workup

  1. concentrationThe mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-57cff594de224c42a16d335ca7ca622e
Source dataset
uspto-grants-2013_09
Patent number
US08530461B2

Reaction notes

Loading…