HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40509Generated: October 27, 2026
Trifluoroacetic acid → (S)-1-{4-[3-(4-Cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethylamine
https://huagongshe.com/reaction/40509
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (1-{4-[3-(4-Cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester | HCID 86689011 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-1-{4-[3-(4-Cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethylamine | HCID 86689012 | — |
Reaction Steps
130 mg (0.30 mmol) (1-{4-[3-(4-cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester are added to 2 mL DCM and the mixture is cooled to 0° C. 0.03 mL TFA is added and stirring is continued for 1 h at 0° C. The solution as such is used directly for subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530461B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-24974738b50841588541457f1be06b46 |
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| Source note | uspto-grants-2013_09 |
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