Tetrahydrofuran → 3-(5-(5-Chloro-2-(((2',4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoic acid

Participants

Reaction Steps

A 3M aqueous solution of NaOH (7.5 mL, 22.6 mmol) was added to a THF (40 mL) and MeOH (20 mL) solution of ethyl 3-(5-(5-chloro-2-(((2′,4′-dichloro-[1,1′-biphenyl]-4-yl)amino)methyl)phenyl)picolinamido)propanoate (6.6 g, 11.3 mmol) and the resulting homogeneous mixture was stirred at room temperature. After 16 h the resulting mixture was concentrated in vacuo, suspended in water, and acidified with 2 M HCl. The resulting precipitate was filtered off and dried in vacuo to yield the title compound.

Provenance & Evidence