HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 71060082, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| Reactant | HCID 71059974 | HCID 71059974 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 71060082 | HCID 71060082 | — |
Reaction Steps
tert-butyl 3-(5-(2-(((4-bromophenyl)amino)methyl)phenyl)picolinamido)propanoate (80 mg, 0.16 mmol), (3,4-dichlorophenyl)boronic acid (34 mg, 0.18 mmol), Pd(dppf)Cl2 (13 mg, 0.02 mmol), and K2CO3 (43 mg, 0.31 mmol) were dissolved in 1,4-dioxane (1.2 mL) and water (0.3 mL) and heated to 80° C. After 3 h the resulting mixture was cooled to room temperature, diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-f113f8437f8d4a6c800a84344154aede |
| Source note | uspto-grants-2014_06 |