Potassium Carbonate → Methyl 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(4-Chlorophenyl)-N-methylaniline	HCID 15622744	—
반응물	Methyl 5-(2-(bromomethyl)-5-chlorophenyl)picolinate	HCID 86674247	—
용매	Acetone	HCID 180	—
용매	Ethyl Acetate	HCID 8857	—
생성물	Methyl 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinate	HCID 71059984	—

반응 조건

온도	50 °C

반응 단계

Methyl 5-(2-(bromomethyl)-5-chlorophenyl)picolinate (200 mg, 0.59 mmol), 4′-chloro-N-methyl-[1,1′-biphenyl]-4-amine (141 mg, 0.65 mmol), and K2CO3 (122 mg, 0.88 mmol) were diluted with acetone (3 mL) and heated to 50° C. After 18 h the resulting mixture was diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08748624B2
출처 데이터셋	uspto-grants-2014_06
ORD ID	ord-55d02b368df94ed48396974f2a5eab8b
출처 메모	uspto-grants-2014_06