Tetrahydrofuran → 3-(5-(5-Chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinamido)propanoic acid

Participants

Reaction Steps

A 3M aqueous solution of NaOH (0.29 mL, 0.88 mmol) was added to a THF (2 mL) and MeOH (1 mL) solution of ethyl 3-(5-(5-chloro-2-(((4′-chloro-[1,1′-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinamido)propanoate (165 mg, 0.29 mmol) and the resulting homogeneous mixture was stirred at room temperature. After 16 h the mixture was concentrated in vacuo, suspended in water, and acidified with 2 M HCl. The resulting precipitate was filtered off and dried in vacuo to yield the title compound.

Provenance & Evidence