Acetic Acid → N-(2-bromo-4-(trifluoromethyl)benzyl)-2',4'-dichloro-[1,1'-biphenyl]-4-amine

참여 물질

역할	이름	HCID	투입량
반응물	Acetic Acid	HCID 176	—
반응물	2-Bromo-4-(trifluoromethyl)benzaldehyde	HCID 3020373	—
반응물	Sodium triacetoxyborohydride	HCID 5049666	—
반응물	2',4'-Dichloro-[1,1'-biphenyl]-4-amine	HCID 9964725	—
용매	1,2-Dichloroethane	HCID 11	—
용매	Ethyl Acetate	HCID 8857	—
생성물	N-(2-bromo-4-(trifluoromethyl)benzyl)-2',4'-dichloro-[1,1'-biphenyl]-4-amine	HCID 86674248	—

반응 단계

Solid NaBH(OAc)3 (39 mg, 1.9 mmol) was added to a DCE solution (3 mL) of 2-bromo-4-(trifluoromethyl)benzaldehyde (235 mg, 0.9 mmol), 2′,4′-dichloro-[1,1-biphenyl]-4-amine (233 g, 1.0 mmol), and AcOH (0.21 mL, 3.7 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture diluted with EtOAc washed with water and brine, dried (Na2SO4), dry-packed onto silica gel and purified via column chromatography to yield the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08748624B2
출처 데이터셋	uspto-grants-2014_06
ORD ID	ord-8b6644c6bc9e4121ba9cb39d95026e5a
출처 메모	uspto-grants-2014_06