HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-tert-Butyl (1-(4-bromophenyl)ethyl)carbamate → (S)-(1-{4-[3-(4-Cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-tert-Butyl (1-(4-bromophenyl)ethyl)carbamate | HCID 56973617 | — |
| Reactant | 3-(4-Cyclopropylmethoxy-phenoxy)-azetidine | HCID 86689009 | — |
| Product | (S)-(1-{4-[3-(4-Cyclopropylmethoxy-phenoxy)-azetidin-1-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester | HCID 86689020 | — |
Reaction Steps
Example 8.3 is prepared analogously to 8.1. (S)-[1-(4-Bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester (1.3) and 3-(4-cyclopropylmethoxy-phenoxy)-azetidine (IX.1) are used as starting materials and the reaction temperature is 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530461B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-200bcd6a9a8d4b3ba3a6b42cc725c895 |
| Source note | uspto-grants-2013_09 |