HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2-bromo-N-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-4,5-difluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Bromo-4,5-difluorobenzoic acid | HCID 2782789 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2',4'-Dichloro-[1,1'-biphenyl]-4-amine | HCID 9964725 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-bromo-N-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-4,5-difluorobenzamide | HCID 71059866 | — |
Reaction Steps
Solid HATU (501 mg, 1.3 mmol) was added to a DMF solution (1 mL) of 2-bromo-4,5-difluorobenzoic acid (250 mg, 1.1 mmol), i-Pr2NEt (0.5 mL, 3.2 mmol), and 2′,4′-dichloro-[1,1′-biphenyl]-4-amine (251 mg, 1.1 mmol) and the resulting mixture was stirred at room temperature. After 2 h the resulting mixture was directly purified via column chromatography to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-6b98ecef57a34f1a915b0653d220e2ad |
| Source note | uspto-grants-2014_06 |