Sodium Hydroxide → 3-(5-(2-((2',4'-Dichloro-[1,1'-biphenyl]-4-yl)carbamoyl)-4,5-difluorophenyl)picolinamido)propanoic acid

Participants

Reaction Steps

A 3M aqueous solution of NaOH (0.27 mL, 0.82 mmol) was added to a THF solution (0.9 mL) of ethyl 3-(5-(2-((2′,4′-dichloro-[1,1′-biphenyl]-4-yl)carbamoyl)-4,5-difluorophenyl)picolinamido)propanoate (100 mg, 0.17 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture was concentrated and purified via HPLC to yield the title compound.

Provenance & Evidence