3-(4-Ethoxyphenoxy)azetidine → N-(1-{6-[3-(4-Ethoxy-phenoxy)-azetidin-1-yl]-pyridin-3-yl}-ethyl)-acetamide

HRID 40521Notes

Reaction equation

HRID 40521 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([CH:8]([NH:10][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:4][CH:3]=1.[CH2:14]([O:16][C:17]1[CH:27]=[CH:26][C:20]([O:21][CH:22]2[CH2:25][NH:24][CH2:23]2)=[CH:19][CH:18]=1)[CH3:15]>>[CH2:14]([O:16][C:17]1[CH:27]=[CH:26][C:20]([O:21][CH:22]2[CH2:25][N:24]([C:2]3[N:7]=[CH:6][C:5]([CH:8]([NH:10][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:4][CH:3]=3)[CH2:23]2)=[CH:19][CH:18]=1)[CH3:15]

Participants

3

Reactant 2

HCID 534093113-(4-Ethoxyphenoxy)azetidineHCID 86689003N-[1-(6-Bromo-pyridin-3-yl)-ethyl]acetamide

Product 1

HCID 86689021N-(1-{6-[3-(4-Ethoxy-phenoxy)-azetidin-1-yl]-pyridin-3-yl}-ethyl)-acetamide

Procedure

Example 8.6 is prepared analogously to 8.1. (N-[1-(6-Bromo-pyridin-3-yl)-ethyl]-acetamide (I.4) and 3-(4-ethoxy-phenoxy)-azetidine are used as starting materials.

Workup

  1. customExample 8.6 is prepared analogously to 8.1

Sources & evidence

ORD record
ord-999e02af476b4054b4a368e767cc429a
Source dataset
uspto-grants-2013_09
Patent number
US08530461B2

Reaction notes

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