HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 71059956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (4-Fluoro-3-methylphenyl)boronic acid | HCID 2774580 | — |
| Reactant | HCID 71059597 | HCID 71059597 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 71059956 | HCID 71059956 | — |
Reaction Steps
Methyl 3-(5-(5-chloro-2-(((4-iodophenyl)amino)methyl)phenyl)picolinamido)propanoate (83 mg, 0.15 mmol), (4-fluoro-3-methylphenyl)boronic acid (31 mg, 0.20 mmol), Pd(dppf)Cl2 (12 mg, 0.02 mmol), and K2CO3 (55 mg, 0.40 mmol) were dissolved in 1,4-dioxane (1.5 mL) and water (0.5 mL) and heated to 90° C. After 1.5 h the resulting mixture was diluted with DCM, dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-c55162f4029b41e58fcf2a3d94aac2e2 |
| Source note | uspto-grants-2014_06 |