4-Bromo-3-chloroaniline → HCID 86674294, compound

HRID 405264Notes

Reaction equation

HRID 405264 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[O:9][CH3:10].[Cl:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[C:14]([CH3:21])[CH:13]=1.BrC1C=CC(N)=CC=1Cl.FC(F)(F)C1C=CC(B(O)O)=CC=1>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[O:9][CH3:10])=[C:14]([CH3:21])[CH:13]=1

Participants

5

Reactant 4

HCID 888884-Bromo-3-chloroanilineHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 5017600(4-Chloro-2-methylphenyl)boronic acidHCID 70182544-Bromo-3-methoxyaniline

Product 1

HCID 86674294HCID 86674294, compound

Procedure

The title compound was prepared as described in Example 159 substituting 4-bromo-3-methoxyaniline and (4-chloro-2-methylphenyl)boronic acid for 4-bromo-3-chloroaniline and (4-(trifluoromethyl)phenyl)boronic acid, respectively.

Sources & evidence

ORD record
ord-12958db5a83c46e991ed7a58d993f3cc
Source dataset
uspto-grants-2014_06
Patent number
US08748624B2

Reaction notes

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