HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-3-chloroaniline → 2-Methoxy-2'-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-3-chloroaniline | HCID 88888 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 4-Bromo-3-methoxyaniline | HCID 7018254 | — |
| Reactant | 2-Methyl-4-(trifluoromethyl)benzeneboronic acid | HCID 44558152 | — |
| Product | 2-Methoxy-2'-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine | HCID 86674295 | — |
Reaction Steps
The title compound was prepared as described in Example 159 substituting 4-bromo-3-methoxyaniline and (2-methyl-4-(trifluoromethyl)phenyl)boronic acid for 4-bromo-3-chloroaniline and (4-(trifluoromethyl)phenyl)boronic acid, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-9341a2f8645449ecae6328eb517405fe |
| Source note | uspto-grants-2014_06 |