2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine

HRID 405317Notes

Reaction equation

HRID 405317 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][CH:12]=1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][C:11]2[CH:19]=[C:18]3[C:14]([CH:15]=[CH:16][NH:17]3)=[CH:13][CH:12]=2)[C:5]([F:9])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 2560966-Aminoindole

Product 1

HCID 220604592-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine

Procedure

In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to provide 2-chloro-5-fluoro-N4-[(1H)— indol-6-yl]-4-pyrimidineamine. LCMS: purity: 92%; MS (m/e): 263 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-27eb3c748c4e42328ddeb453bfdedcbc
Source dataset
uspto-grants-2014_06
Patent number
US08748597B2

Reaction notes

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