HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-[(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | 3-Methyl-5-(4-nitrophenoxymethyl)-1,2,4-oxadiazole | HCID 22060445 | — |
| Product | 4-[(3-Methyl-1,2,4-oxadiazol-5-yl)methoxy]aniline | HCID 22060873 | — |
Reaction Steps
In like manner to the preparation of 5-[(4-aminophenoxy)methyl]-3-phenyl-1,2,4-oxadiazole, 5-(4-nitrophenoxymethyl)-3-methyl-1,2,4-oxadiazole was reacted with aqueous solution of sodium hydrosulfite and K2CO3 to prepare 5-[(4-aminophenox)ymethyl]-3-methyl-1,2,4-oxadiazole. 1H NMR (CDCl3): δ 6.82 (d, 2H, J=8.8 Hz), 6.63 (d, 2H, J=8.8 Hz), 5.15 (s, 2H), 3.38 (br s, 2H), 2.41 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748597B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b25c922b4e5b4df187fcd76c6090adb7 |
| Source note | uspto-grants-2014_06 |