反应详情

A mixture of 7.00 g (46.6 mmol) 4-hydroxyphenylacetone and 200 mL 7N ammonia in MeOH is charged with 0.70 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (50 psi) at r.t. over night. After complete reaction, the mixture is filtrated, the solvent is removed in vacuo and the crude product is purified by HPLC (MeOH/H2O/NH3).

1. customAfter complete reaction
2. filtrationthe mixture is filtrated
3. customthe solvent is removed in vacuo
4. customthe crude product is purified by HPLC (MeOH/H2O/NH3)