HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40563Generated: October 26, 2026
Acetonitrile → 5-Bromo-N-sec-butylpyrimidin-2-amine
https://huagongshe.com/reaction/40563
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Sec-Butylamine | HCID 24874 | — |
| Reactant | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Bromo-N-sec-butylpyrimidin-2-amine | HCID 63873787 | — |
Reaction Steps
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo. C8H12BrN3 (M=230.1 g/mol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530460B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-1d99d59c38ef44dfa691cbcecf9f42e2 |
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| Source note | uspto-grants-2013_09 |
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