tert-Butylsulfinamide, (R)-(+)- → HCID 178455587, compound

HRID 405709Notes

Reaction equation

HRID 405709 reaction equation
[F:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11])=O.[C:12]([S@:16]([NH2:18])=[O:17])([CH3:15])([CH3:14])[CH3:13]>>[F:1][CH2:2]/[C:3](=[N:18]\[S@@:16]([C:12]([CH3:15])([CH3:14])[CH3:13])=[O:17])/[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[F:11]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 219644912-Fluoro-1-(2-fluoro-phenyl)-ethanone

Product 1

HCID 178455587HCID 178455587, compoundYield 52%

Procedure

In a manner analogous to that described for the preparation of sulfinyl imine A2.1 the reaction of 2-fluoro-1-(2-fluoro-phenyl)-ethanone with (R)-tert-butylsulfinamide yielded the (R)-2-methyl-propane-2-sulfinic acid [2-fluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-amide (52% of theory) as an orange oil. MS (ISP): m/z=260.2 [M+H]+.

Sources & evidence

ORD record
ord-41e92b303e164a5fa1b8796be8798c2c
Source dataset
uspto-grants-2014_06
Patent number
US08754075B2

Reaction notes

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