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HRID 405715作成日：2026年10月26日

3,5-Difluoropyridine-2-carboxylic acid → 3,5-Difluoro-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/405715

反応式

関与物質

役割名称HCID仕込み量
反応物3,5-Difluoropyridine-2-carboxylic acidHCID 2783262—
反応物(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
生成物3,5-Difluoro-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66557906—

反応手順

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 3,5-difluoro-pyridine-2-carboxylic acid (CAS 745784-04-7) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=383.3 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08754075B2
出典データセットuspto-grants-2014_06
ORD IDord-77f92d78f78d4f7eaf54a8711cf987a7
出典メモuspto-grants-2014_06