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HRID405720

反应详情

EQUATION

反应方程式

HRID 405720 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1ncc(C(F)(F)F)cc1Cl
HCID2821908

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid

C7H3ClF3NO2

结构：C[C@]1(c2cc(N)ccc2F)N=C(N)OC[C@@H]1F
HCID86672004

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]1(c2cc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F
HCID66558686

未命名化合物

PROCEDURE

实验过程

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid (CAS 80194-68-9) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=449.1 [M+H]+.