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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 405725Generated: October 31, 2026

HCID 57475876, compound → HCID 66558691, compound

https://huagongshe.com/reaction/405725

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 57475876HCID 57475876—
Reactant(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
ProductHCID 66558691HCID 66558691—

Reaction Steps

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 5-cyclopropylethynyl-pyridine-2-carboxylic acid (CAS 1174322-62-3; WO2009091016) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=411.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08754075B2
Source datasetuspto-grants-2014_06
ORD IDord-f0a8f03fd745445c988b12e47e251943
Source noteuspto-grants-2014_06